Clinical Assessment of Cosmetic Safety
At PhD Trials®, we routinely perform In vivo Safety studies (HRIPT, Patch Tests, ROATS, Open Tests) to evaluate cosmetic products and raw materials.
We have an extensive database of volunteers with several typologies (sensitive/reactive, atopic, acne prone and normal skin), and an experienced team to perform in vivo safety studies.
We have an extensive database of volunteers with several typologies (sensitive/reactive, atopic, acne prone and normal skin), and an experienced team to perform in vivo safety studies.
Our main safety studies are:
- Human Repeated Insult Patch Test (HRIPT)
- Single or Repeated Patch Test
- Open tests
- Repeated Open Application Tests (ROAT)
- In use studies for tolerance evaluation
- Comedogenicity studies
In vivo efficacy: General Methods
PhD Trials® is the laboratory to substantiate your claim. We have all the general methods to study the interaction of your product with the human skin.
We are worldwide recognized for having developed some of the most used techniques to substantiate the efficacy of cosmetic products:
- Skin hydration
- Trans Epidermal Water Loss (TEWL)
- Skin color
- Skin Lipids
- Skin Rheology
- Skin pH
In vivo efficacy: Advanced Methods
From Confocal microscopy, AEVA-HE, skin microcirculation and professional imaging studios (with high resolution cameras and VISIA-CR), at PhD Trials we can show how good your product is. At PhD Trials®, we design specific studies to your claims. We are recognized for our very complete reports in all studies. Our advanced clinical photography laboratories are fully equipped to perform digital and 3D photos (AEVA, Vectra and Primos systems) from all parts of the body in high detail and resolution to help the visualization of the effects of your product.
Some of our advanced tests are:
- Skin thickness
- Skin topography evaluation
- Skin temperature & structure
- Skin 3D topography
- Face evaluation
- Standardized photography
- Assessment of cutaneous barrier
- Moisturizing comparison
- Cutaneous vitality
- Anti-oxidant effects
Hair Physiology Evaluation
Hair products are among the most used cosmetic products.
Our new Hair Evaluation Lab was developed to study the human hair in several conditions (in vivo and ex vivo).
Our new Hair Evaluation Lab was developed to study the human hair in several conditions (in vivo and ex vivo).
- In vivo studies – Clinical evaluation, Visioscan, Image analysis
- Ex vivo evaluation – Hair tresses with specific chamber, Hair tresses with combing machine, Hair tresses with force system, Image analysis, UV protection, Color protection of hair against repetitive washing, Wet and Dry combing, Thermal protection, Anti-frizz effect, Volume effect, Shining effect, Smoothness effect
- Hair evaluation – TrichoScan HD for Hair grow, density and anagen/telogen rate
Cosmetic Consulting
The European Cosmetic Regulation presented challenges that can only be solved with experienced consultants.
At PhD Trials® we perform safety assessments of finished cosmetic products, new formulation development and improvement according with the European regulations.
Quality Control
In vitro testing for claim substantiation and product development, (e.g. Het-CAM, BCOP).
Microbiology control, Microbiology Challenge test.
Stability testing, PAO evaluation.